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(A) Known species and Operational Taxonomic Units (OTUs) (green circles) linked to metabolic syndrome traits (yellow diamonds), illustrating statistically significant correlation coefficients using the Louvain algorithm. The size of the circles represents the mean relative abundance in the Amish cohort studied. Numbers connecting microbes are the correlation coefficient (p<0.001 for all). Solid lines represent positive correlations and dashed lines represent inverse correlations. (B) The same network as shown in panel A, but also including the statistically significant associations between bacterial taxa. (C) Phylogenetic tree of <t>16S</t> <t>rRNA</t> sequences from the bacterial taxa in this network using the R implementation of DNADIST and FASTME. OTUs and known species that are inversely correlated with metabolic syndrome traits are colored in red and that are positively correlated with metabolic syndrome traits are colored in blue (p<0.001 for all).
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(A) Known species and Operational Taxonomic Units (OTUs) (green circles) linked to metabolic syndrome traits (yellow diamonds), illustrating statistically significant correlation coefficients using the Louvain algorithm. The size of the circles represents the mean relative abundance in the Amish cohort studied. Numbers connecting microbes are the correlation coefficient (p<0.001 for all). Solid lines represent positive correlations and dashed lines represent inverse correlations. (B) The same network as shown in panel A, but also including the statistically significant associations between bacterial taxa. (C) Phylogenetic tree of <t>16S</t> <t>rRNA</t> sequences from the bacterial taxa in this network using the R implementation of DNADIST and FASTME. OTUs and known species that are inversely correlated with metabolic syndrome traits are colored in red and that are positively correlated with metabolic syndrome traits are colored in blue (p<0.001 for all).
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(A) Known species and Operational Taxonomic Units (OTUs) (green circles) linked to metabolic syndrome traits (yellow diamonds), illustrating statistically significant correlation coefficients using the Louvain algorithm. The size of the circles represents the mean relative abundance in the Amish cohort studied. Numbers connecting microbes are the correlation coefficient (p<0.001 for all). Solid lines represent positive correlations and dashed lines represent inverse correlations. (B) The same network as shown in panel A, but also including the statistically significant associations between bacterial taxa. (C) Phylogenetic tree of <t>16S</t> <t>rRNA</t> sequences from the bacterial taxa in this network using the R implementation of DNADIST and FASTME. OTUs and known species that are inversely correlated with metabolic syndrome traits are colored in red and that are positively correlated with metabolic syndrome traits are colored in blue (p<0.001 for all).
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(A) Known species and Operational Taxonomic Units (OTUs) (green circles) linked to metabolic syndrome traits (yellow diamonds), illustrating statistically significant correlation coefficients using the Louvain algorithm. The size of the circles represents the mean relative abundance in the Amish cohort studied. Numbers connecting microbes are the correlation coefficient (p<0.001 for all). Solid lines represent positive correlations and dashed lines represent inverse correlations. (B) The same network as shown in panel A, but also including the statistically significant associations between bacterial taxa. (C) Phylogenetic tree of <t>16S</t> <t>rRNA</t> sequences from the bacterial taxa in this network using the R implementation of DNADIST and FASTME. OTUs and known species that are inversely correlated with metabolic syndrome traits are colored in red and that are positively correlated with metabolic syndrome traits are colored in blue (p<0.001 for all).
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(A) Known species and Operational Taxonomic Units (OTUs) (green circles) linked to metabolic syndrome traits (yellow diamonds), illustrating statistically significant correlation coefficients using the Louvain algorithm. The size of the circles represents the mean relative abundance in the Amish cohort studied. Numbers connecting microbes are the correlation coefficient (p<0.001 for all). Solid lines represent positive correlations and dashed lines represent inverse correlations. (B) The same network as shown in panel A, but also including the statistically significant associations between bacterial taxa. (C) Phylogenetic tree of <t>16S</t> <t>rRNA</t> sequences from the bacterial taxa in this network using the R implementation of DNADIST and FASTME. OTUs and known species that are inversely correlated with metabolic syndrome traits are colored in red and that are positively correlated with metabolic syndrome traits are colored in blue (p<0.001 for all).
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(A) Known species and Operational Taxonomic Units (OTUs) (green circles) linked to metabolic syndrome traits (yellow diamonds), illustrating statistically significant correlation coefficients using the Louvain algorithm. The size of the circles represents the mean relative abundance in the Amish cohort studied. Numbers connecting microbes are the correlation coefficient (p<0.001 for all). Solid lines represent positive correlations and dashed lines represent inverse correlations. (B) The same network as shown in panel A, but also including the statistically significant associations between bacterial taxa. (C) Phylogenetic tree of <t>16S</t> <t>rRNA</t> sequences from the bacterial taxa in this network using the R implementation of DNADIST and FASTME. OTUs and known species that are inversely correlated with metabolic syndrome traits are colored in red and that are positively correlated with metabolic syndrome traits are colored in blue (p<0.001 for all).
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(A) Known species and Operational Taxonomic Units (OTUs) (green circles) linked to metabolic syndrome traits (yellow diamonds), illustrating statistically significant correlation coefficients using the Louvain algorithm. The size of the circles represents the mean relative abundance in the Amish cohort studied. Numbers connecting microbes are the correlation coefficient (p<0.001 for all). Solid lines represent positive correlations and dashed lines represent inverse correlations. (B) The same network as shown in panel A, but also including the statistically significant associations between bacterial taxa. (C) Phylogenetic tree of <t>16S</t> <t>rRNA</t> sequences from the bacterial taxa in this network using the R implementation of DNADIST and FASTME. OTUs and known species that are inversely correlated with metabolic syndrome traits are colored in red and that are positively correlated with metabolic syndrome traits are colored in blue (p<0.001 for all).
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(A) Known species and Operational Taxonomic Units (OTUs) (green circles) linked to metabolic syndrome traits (yellow diamonds), illustrating statistically significant correlation coefficients using the Louvain algorithm. The size of the circles represents the mean relative abundance in the Amish cohort studied. Numbers connecting microbes are the correlation coefficient (p<0.001 for all). Solid lines represent positive correlations and dashed lines represent inverse correlations. (B) The same network as shown in panel A, but also including the statistically significant associations between bacterial taxa. (C) Phylogenetic tree of <t>16S</t> <t>rRNA</t> sequences from the bacterial taxa in this network using the R implementation of DNADIST and FASTME. OTUs and known species that are inversely correlated with metabolic syndrome traits are colored in red and that are positively correlated with metabolic syndrome traits are colored in blue (p<0.001 for all).
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Image Search Results


(A) Known species and Operational Taxonomic Units (OTUs) (green circles) linked to metabolic syndrome traits (yellow diamonds), illustrating statistically significant correlation coefficients using the Louvain algorithm. The size of the circles represents the mean relative abundance in the Amish cohort studied. Numbers connecting microbes are the correlation coefficient (p<0.001 for all). Solid lines represent positive correlations and dashed lines represent inverse correlations. (B) The same network as shown in panel A, but also including the statistically significant associations between bacterial taxa. (C) Phylogenetic tree of 16S rRNA sequences from the bacterial taxa in this network using the R implementation of DNADIST and FASTME. OTUs and known species that are inversely correlated with metabolic syndrome traits are colored in red and that are positively correlated with metabolic syndrome traits are colored in blue (p<0.001 for all).

Journal: PLoS ONE

Article Title: Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome

doi: 10.1371/journal.pone.0043052

Figure Lengend Snippet: (A) Known species and Operational Taxonomic Units (OTUs) (green circles) linked to metabolic syndrome traits (yellow diamonds), illustrating statistically significant correlation coefficients using the Louvain algorithm. The size of the circles represents the mean relative abundance in the Amish cohort studied. Numbers connecting microbes are the correlation coefficient (p<0.001 for all). Solid lines represent positive correlations and dashed lines represent inverse correlations. (B) The same network as shown in panel A, but also including the statistically significant associations between bacterial taxa. (C) Phylogenetic tree of 16S rRNA sequences from the bacterial taxa in this network using the R implementation of DNADIST and FASTME. OTUs and known species that are inversely correlated with metabolic syndrome traits are colored in red and that are positively correlated with metabolic syndrome traits are colored in blue (p<0.001 for all).

Article Snippet: We performed 16S rRNA multiplex pyrosequencing of V1–V3 amplicons using bar-coded primers on the 454 Titanium platform to characterize the fecal microbiota.

Techniques: